BPTU
Tocris Bioscience, part of Bio-Techne | Catalog # 6078
P2Y1 allosteric antagonist
Product Description
BPTU is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.Product Specifications
Molecular Weight
445.43
Formula
C23H22F3N3O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
CAS Number
870544-59-5
PubChem ID
11510579
InChI Key
AHFLGPTXSIRAQK-UHFFFAOYSA-N
SMILES
CC(C)(C1=C(C=CC=C1)OC2=C(C=CC=N2)NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.54 | 100 | |
| Ethanol | 44.54 | 100 |
Preparing Stock Solutions
for BPTU
The following data is based on the product molecular weight 445.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.23 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 PMID: 25822790
- Mañé BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology. 2016 PMID: 27496690
- Chao Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J.Med.Chem. 2013 PMID: 23368907
Product Specific Notices for BPTU
For research use only
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