BMS 566419
Tocris Bioscience, part of Bio-Techne | Catalog # 5492
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Key Product Details
Description
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Product Description
BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.Product Specifications
Molecular Weight
487.57
Formula
C28H30FN5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
CAS Number
566161-24-8
PubChem ID
9913339
InChI Key
XEVJUIZOZCFECP-UHFFFAOYSA-N
SMILES
O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 24.38 | 50 | |
| DMSO | 48.76 | 100 |
Preparing Stock Solutions
for BMS 566419
The following data is based on the product molecular weight 487.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.25 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.10 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for BMS 566419
For research use only
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