BMS 466442
Tocris Bioscience, part of Bio-Techne | Catalog # 6878
Potent and selective inhibitor of asc-1
Key Product Details
Description
Potent and selective inhibitor of asc-1
Product Description
BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC50 values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.Product Specifications
Molecular Weight
538.60
Formula
C31H30N4O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
CAS Number
1598424-76-0
PubChem ID
124082063
InChI Key
UUCAHZCMRZOTNF-MHZLTWQESA-N
SMILES
COC(=O)[C@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)C1=CC2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.86 | 100 |
Preparing Stock Solutions
for BMS 466442
The following data is based on the product molecular weight 538.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.28 mL | 18.57 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brown In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 2014 PMID: 24266811
- Torrecillas Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 2019 PMID: 30821959
Product Specific Notices for BMS 466442
For research use only
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