BIX NHE1 inhibitor

Name: BIX NHE1 inhibitor
Brand: Tocris Bioscience
SKU: 5512

Tocris Bioscience a Bio-Techne Brand

Catalog # 5512

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Key Product Details

Description:	Potent and selective NHE1 inhibitor
Chemical Name:	4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	392.8

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Biological Activity for BIX NHE1 inhibitor

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC₅₀ = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Technical Data for BIX NHE1 inhibitor

M. Wt	392.8
Formula	C₁₆H₁₉F₃N₄O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1422252-46-7
PubChem ID	121513866
InChi Key	SLSZLEROFKLICF-UHFFFAOYSA-N
Smiles	CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIX NHE1 inhibitor

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.64	50

Preparing Stock Solutions for BIX NHE1 inhibitor

The following data is based on the product molecular weight 392.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.09 mL	25.46 mL	50.92 mL
2.5 mM	1.02 mL	5.09 mL	10.18 mL
5 mM	0.51 mL	2.55 mL	5.09 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References for BIX NHE1 inhibitor

References are publications that support the biological activity of the product.

Kilić Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 2014 PMID: 25216745
Huber Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 2012 PMID: 22803959

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BIX NHE1 inhibitor

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Biological Activity for BIX NHE1 inhibitor

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Reconstitution Calculator

References for BIX NHE1 inhibitor

Citations for BIX NHE1 inhibitor

Product Documents for BIX NHE1 inhibitor

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