BIX 02189

Tocris Bioscience, part of Bio-Techne | Catalog # 4842

Selective MEK5 and ERK5 inhibitor
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Key Product Details

Description

Selective MEK5 and ERK5 inhibitor

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Product Description

BIX 02189 is a selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

Product Specifications

Molecular Weight

440.54

Formula

C27H28N4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

CAS Number

1265916-41-3

PubChem ID

46931012

InChI Key

HOMJAAIVTDVQJA-IZHYLOQSSA-N

SMILES

O=C2NC1=CC(C(N(C)C)=O)=CC=C1/C2=C(C4=CC=CC=C4)/NC3=CC(CN(C)C)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 44.05 100
DMSO 44.05 100

Preparing Stock Solutions for BIX 02189

The following data is based on the product molecular weight 440.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.70 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for BIX 02189

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIX 02189

For research use only

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