BIMU 8
Tocris Bioscience, part of Bio-Techne | Catalog # 4374
Potent 5-HT4 agonist
Product Description
BIMU 8 is a potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.Product Specifications
Molecular Weight
378.90
Formula
C19H26N4O2.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
CAS Number
134296-40-5
PubChem ID
5311028
InChI Key
NQYXXIUVFVOJCX-XZPOUAKSSA-N
SMILES
[H][C@]12CC[C@](CC(NC(N3C(C=CC=C4)=C4N(C(C)C)C3=O)=O)C2)([H])N1C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.42 | 75 | |
| DMSO | 37.89 | 100 |
Preparing Stock Solutions
for BIMU 8
The following data is based on the product molecular weight 378.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.20 mL | 26.39 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.28 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schaus Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 1998 PMID: 9599243
- Pellissier Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 2009 PMID: 19168624
Product Specific Notices for BIMU 8
For research use only
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