BIBX 1382 dihydrochloride

Name: BIBX 1382 dihydrochloride
Brand: Tocris Bioscience
SKU: 2416
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2416

(2)

Citations (4)

COA / SDS

Highly selective EGFR-kinase inhibitor

Discontinued Product

2416 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description:	Highly selective EGFR-kinase inhibitor
Chemical Name:	N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	460.77

View Full Technical Details for BIBX 1382 dihydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for BIBX 1382 dihydrochloride

BIBX 1382 dihydrochloride is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC₅₀ = 3.4 μM) and a range of other related tyrosine kinases (IC₅₀ > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.

Technical Data for BIBX 1382 dihydrochloride

M. Wt	460.77
Formula	C₁₈H₁₉ClFN₇.2HCl
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	1216920-18-1
PubChem ID	46861540
InChi Key	RFXGEKWBTCMDAW-UHFFFAOYSA-N
Smiles	Cl.Cl.CN1CCC(CC1)NC1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BIBX 1382 dihydrochloride

References are publications that support the biological activity of the product.

Solca Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 2004 PMID: 15199094
Dittrich Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur.J.Cancer 2002 PMID: 12008195

BIBX 1382 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2416

Key Product Details

Biological Activity for BIBX 1382 dihydrochloride

Technical Data for BIBX 1382 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BIBX 1382 dihydrochloride

Product Documents for BIBX 1382 dihydrochloride

COA

Certificate of Analysis

SDS

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