BIBP 3226 trifluoroacetate

Name: BIBP 3226 trifluoroacetate
Brand: Tocris Bioscience
SKU: 2707

Catalog # 2707 | Tocris Bioscience a Bio-Techne Brand

Citations (14)

COA / SDS

Mixed NPY Y1 and NPFF receptor antagonist

Key Product Details

Description:	Mixed NPY Y₁ and NPFF receptor antagonist
Chemical Name:	N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate
Purity:	≥98% (HPLC)

View Full Technical Details for BIBP 3226 trifluoroacetate

Technical Data
Citations (14) / Reviews

Biological Activity for BIBP 3226 trifluoroacetate

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

Technical Data for BIBP 3226 trifluoroacetate

Formula	C₂₇H₃₁N₅O₃.xCF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	121513845
InChi Key	FSBMUMHPXBMVJF-MQWQBNKOSA-N
Smiles	OC1=CC=C(CNC([C@H](NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CCCNC(N)=N)=O)C=C1.OC(C(F)(F)F)=O
M. Wt	473.57 (Free Base)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIBP 3226 trifluoroacetate

Solubility

Soluble to 1mg/ml in water and to 50mg/ml in DMSO

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References for BIBP 3226 trifluoroacetate

References are publications that support the biological activity of the product.

Fang In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 2006 PMID: 16762456
Mollereau Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 2001 PMID: 11325787
Kask Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with D.pam. Eur.J.Pharmacol. 1996 PMID: 8997632

Citations for BIBP 3226 trifluoroacetate (14)

Showing 1 - 10 of 14 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for BIBP 3226 trifluoroacetate include:

Acton et al. (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep. 28:625
PMID: 31315043
Businaro et al. (2018) Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep. 8(1):14365
PMID: 30254326
Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun. 8(1):189
PMID: 28775269
Martins et al. (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 7
PMID: 26311075
Pleil et al. (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 18:545
PMID: 25751534
Aveleira et al. (2015) Neuropeptide Y stimulates autophagy in hypothalamic neurons. Cell Death Dis. 112:E1642
PMID: 25775546
Zacharia et al. (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One. 8:e65969
PMID: 23776582
Reidelberger et al. (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab. 304:E944
PMID: 23482449
Santos-Carvalho et al. (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Proc Natl Acad Sci U S A. 4:e636
PMID: 23681231
Yi et al. (2012) Glucocorticoid signaling in the arcuate nucleus modulates hepatic Ins sensitivity. Diabetes. 61:339
PMID: 22210324
Novielli et al. (2012) Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS One. 7:e46659
PMID: 23071607
Pleil et al. (2012) Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 62:1777
PMID: 22182779
Sparrow et al. (2012) Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Proc Natl Acad Sci U S A. 37:1409
PMID: 22218088
Son et al. (2011) Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self-renewal and proliferation of human embryonic stem cells. J Cell Mol Med. 15:152
PMID: 19874423

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