BIBP 3226 trifluoroacetate

Name: BIBP 3226 trifluoroacetate
Brand: Tocris Bioscience
SKU: 2707

Tocris Bioscience, part of Bio-Techne | Catalog # 2707

Citations (14)

COA / SDS

Mixed NPY Y1 and NPFF receptor antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Mixed NPY Y1 and NPFF receptor antagonist

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Product Description

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

Product Specifications

Formula

C₂₇H₃₁N₅O₃.xCF₃CO₂H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate

PubChem ID

121513845

InChI Key

FSBMUMHPXBMVJF-MQWQBNKOSA-N

SMILES

OC1=CC=C(CNC([C@H](NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CCCNC(N)=N)=O)C=C1.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water and to 50mg/ml in DMSO

Calculators

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Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

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Concentration 2 (C2)

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Mollereau Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 2001 PMID: 11325787
Fang In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 2006 PMID: 16762456
Kask Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with D.pam. Eur.J.Pharmacol. 1996 PMID: 8997632