BI 9564
Tocris Bioscience, part of Bio-Techne | Catalog # 5590
Potent and selective BRD9 and BRD7 inhibitor; orally active
Key Product Details
Description
Potent and selective BRD9 and BRD7 inhibitor; orally active
Product Description
BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
353.41
Formula
C20H23N3O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
CAS Number
1883429-22-8
PubChem ID
117072549
InChI Key
BJFSUDWKXGMUKA-UHFFFAOYSA-N
SMILES
O=C(N(C)C=C1C2=CC(OC)=C(CN(C)C)C=C2OC)C3=C1C=CN=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 3.53 | 10 with gentle warming | |
| DMSO | 7.07 | 20 |
Preparing Stock Solutions
for BI 9564
The following data is based on the product molecular weight 353.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.15 mL | 70.74 mL | 141.48 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.30 mL |
| 2 mM | 1.41 mL | 7.07 mL | 14.15 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Karim and Schönbrunn An Advanced Tool To Interrogate BRD9. J.Med.Chem. 2016 PMID: 27120693
- Martin Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 2016 PMID: 26914985
Product Specific Notices for BI 9564
For research use only
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