BI 9321
Tocris Bioscience, part of Bio-Techne | Catalog # 6665
Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
Key Product Details
Description
Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
Product Description
BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.Product Specifications
Molecular Weight
469.81
Formula
C22H21FN4.3HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride
CAS Number
2387510-87-2
InChI Key
DCDXMBVQCRHZMW-UHFFFAOYSA-N
SMILES
CN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 46.98 | 100 | |
| DMSO | 46.98 | 100 |
Preparing Stock Solutions
for BI 9321
The following data is based on the product molecular weight 469.81
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.64 mL | 21.29 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Böttcher Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 2019 PMID: 31285596
Product Specific Notices for BI 9321
For research use only
Loading...
Loading...