BI 3231

Name: BI 3231
Brand: Tocris Bioscience
SKU: 8039

Tocris Bioscience, part of Bio-Techne | Catalog # 8039

COA / SDS

Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor

Key Product Details

Description:	Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor
Chemical Name:	1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)pyrimidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	380.37

View Full Technical Details for BI 3231

Technical Data
Citations

Biological Activity for BI 3231

BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC₅₀ values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; K_i = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.

Technical Data for BI 3231

M. Wt	380.37
Formula	C₁₆H₁₄F₂N₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2894848-07-6
PubChem ID	167312378
InChi Key	XKDHFIPNTTUSIA-UHFFFAOYSA-N
Smiles	O=C1C(C)=CN(CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2)C(N1CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI 3231

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.8	10 with gentle warming

Preparing Stock Solutions for BI 3231

The following data is based on the product molecular weight 380.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.45 mL	262.90 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

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Reconstitution Calculator

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References for BI 3231

References are publications that support the biological activity of the product.

Thamm Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J.Med.Chem. 2023 PMID: 36727857