BI 3231
Tocris Bioscience, part of Bio-Techne | Catalog # 8039
Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor
Key Product Details
Description
Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor
Product Description
BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC50 values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; Ki = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.Product Specifications
Molecular Weight
380.37
Formula
C16H14F2N4O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)pyrimidinedione
CAS Number
2894848-07-6
PubChem ID
167312378
InChI Key
XKDHFIPNTTUSIA-UHFFFAOYSA-N
SMILES
O=C1C(C)=CN(CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2)C(N1CC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.8 | 10 with gentle warming |
Preparing Stock Solutions
for BI 3231
The following data is based on the product molecular weight 380.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.29 mL | 131.45 mL | 262.90 mL |
| 0.5 mM | 5.26 mL | 26.29 mL | 52.58 mL |
| 1 mM | 2.63 mL | 13.15 mL | 26.29 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thamm Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J.Med.Chem. 2023 PMID: 36727857
Product Specific Notices for BI 3231
For research use only
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