BHPI
Tocris Bioscience, part of Bio-Techne | Catalog # 6116
ERα antagonist; also activates unfolded protein response; active in vivo
Key Product Details
Description
ERα antagonist; also activates unfolded protein response; active in vivo
Product Description
BHPI is an estrogen receptor (ER) α inhibitor. Inhibits proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. Induces sustained activation of the unfolded protein response. Active in vivo.Product Specifications
Molecular Weight
331.36
Formula
C21H17NO3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one
CAS Number
56632-39-4
PubChem ID
3860640
InChI Key
FABLAHMQSQFDHR-UHFFFAOYSA-N
SMILES
CC1=CC=CC2=C1NC(C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.14 | 100 | |
| Ethanol | 33.14 | 100 |
Preparing Stock Solutions
for BHPI
The following data is based on the product molecular weight 331.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.60 mL | 3.02 mL | 6.04 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Andruska Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25825714
Product Specific Notices for BHPI
For research use only
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