BF 2649 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3743
Potent and selective H3 inverse agonist
Key Product Details
Description
Potent and selective H3 inverse agonist
Product Description
BF 2649 hydrochloride is a potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.Product Specifications
Molecular Weight
332.31
Formula
C17H26ClNO.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
CAS Number
903576-44-3
PubChem ID
11551689
InChI Key
XLFKECRRMPOAQS-UHFFFAOYSA-N
SMILES
ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.23 | 100 | |
| DMSO | 33.23 | 100 |
Preparing Stock Solutions
for BF 2649 hydrochloride
The following data is based on the product molecular weight 332.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.05 mL | 30.09 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.30 mL | 1.50 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ligneau BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 2007 PMID: 17005916
- Ligneau Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 2007 PMID: 17343831
Product Specific Notices for BF 2649 hydrochloride
For research use only
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