β-GalNAc-PEG4-Azide
Tocris Bioscience, part of Bio-Techne | Catalog # 7780
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Key Product Details
Description
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
Product Description
β-GalNAc-PEG4-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates a single ASGPR ligand with a PEG4 linker and azide group reactive handle ready for conjugation. It can be used as a building block for multivalent compounds to enhance ASGPR binding. Upon binding to ASGPR, β-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. β-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
422.44
Formula
C16H30N4O9
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
CAS Number
879004-92-9
PubChem ID
129115265
InChI Key
DWQAFMMYPUXSPI-IBEHDNSVSA-N
SMILES
[N-]=[N+]=NCCOCCOCCOCCO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)NC(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Sanhueza Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 2017 PMID: 28230359
Product Specific Notices for β-GalNAc-PEG4-Azide
For research use only
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