Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: Tocris Bioscience
SKU: 4117
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4117

Citations (1)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Non-selective Ca²⁺ channel blocker; also NCX inhibitor
Chemical Name:	N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	403

View Full Technical Details for Bepridil hydrochloride

Complete Your Research

Biological Activity for Bepridil hydrochloride

Bepridil hydrochloride is a calcium channel blocker. Also inhibits Na⁺/Ca²⁺ exchange (NCX), sodium channels and cardiac sarcolemmal K_ATP channels; opens mitochondrial K_ATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.

Compound Libraries for Bepridil hydrochloride

Bepridil hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bepridil hydrochloride

M. Wt	403
Formula	C₂₄H₃₄N₂O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	68099-86-5
PubChem ID	50088
InChi Key	JXBBWYGMTNAYNM-UHFFFAOYSA-N
Smiles	CC(C)COCC(N3CCCC3)CN(C2=CC=CC=C2)CC1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bepridil hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.3	100

Preparing Stock Solutions for Bepridil hydrochloride

The following data is based on the product molecular weight 403.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.81 mL
5 mM	0.50 mL	2.48 mL	4.96 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Bepridil hydrochloride

References are publications that support the biological activity of the product.

Sato Bepridil, an antiarrythmic drug, opens mitochondrial K_ATP channels, blocks sarcolemmal K_ATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 2006 PMID: 16174795
Wantanabe and Kimura Blocking effect of bepridil on Na⁺/ Ca²⁺ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 2001 PMID: 11388640
Gill Pharmacology of bepridil. Am.J.Cardiol. 1992 PMID: 1372785
Yatani Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 1986 PMID: 2420970

Citations for Bepridil hydrochloride (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Bepridil hydrochloride include:

Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One. 8:e66113
PMID: 23785474

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Customer Reviews for Bepridil hydrochloride (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Bepridil used on Cav1.2 channels

Name: Anonymous

Species: Human

Product used on Cav1.2 channels to understand it blocking mechanism on the specific channel.

There are no reviews that match your criteria.