Bepridil hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4117
Non-selective Ca2+ channel blocker; also NCX inhibitor
Key Product Details
Description
Non-selective Ca2+ channel blocker; also NCX inhibitor
Product Description
Bepridil hydrochloride is a calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.Product Specifications
Molecular Weight
403.00
Formula
C24H34N2O.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
CAS Number
68099-86-5
PubChem ID
50088
InChI Key
JXBBWYGMTNAYNM-UHFFFAOYSA-N
SMILES
CC(C)COCC(N3CCCC3)CN(C2=CC=CC=C2)CC1=CC=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.3 | 100 |
Preparing Stock Solutions
for Bepridil hydrochloride
The following data is based on the product molecular weight 403.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.81 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gill Pharmacology of bepridil. Am.J.Cardiol. 1992 PMID: 1372785
- Wantanabe and Kimura Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 2001 PMID: 11388640
- Sato Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 2006 PMID: 16174795
- Yatani Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 1986 PMID: 2420970
Product Specific Notices for Bepridil hydrochloride
For research use only
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