Bendamustine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3681
Cytostatic agent; exhibits DNA alkylating and purine analog properties
Discontinued Product
3681 has been discontinued.
View all Apoptosis Inducer Compounds products.
Key Product Details
Description
Cytostatic agent; exhibits DNA alkylating and purine analog properties
Product Description
Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.Product Specifications
Molecular Weight
394.72
Formula
C16H21Cl2N3O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
CAS Number
3543-75-7
PubChem ID
77082
InChI Key
ZHSKUOZOLHMKEA-UHFFFAOYSA-N
SMILES
CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.87 | 25 | |
| DMSO | 39.47 | 100 |
Preparing Stock Solutions
for Bendamustine hydrochloride
The following data is based on the product molecular weight 394.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.67 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Keating Bendamustine. Nat.Rev.Drug Discov. 2008 PMID: 18511926
- Masiello and Tulpule Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 2009 PMID: 19527193
- Schwanen In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 2002 PMID: 12357363
Product Specific Notices for Bendamustine hydrochloride
For research use only
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