BAY 9835
Tocris Bioscience, part of Bio-Techne | Catalog # 8826
Potent ADAMTS7 and ADAMTS12 inhibitor
Product Description
BAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC50 values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.Product Specifications
Molecular Weight
493.39
Formula
C22H16F5N5O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide
CAS Number
3032487-31-0
PubChem ID
170836223
InChI Key
LPQXZOJIUVOCAL-NRFANRHFSA-N
SMILES
O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C(F)=C(C=C1)F)NC[C@@]3(C4=CC=NN4C)NC(NC3=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.34 | 100 |
Preparing Stock Solutions
for BAY 9835
The following data is based on the product molecular weight 493.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.13 mL | 20.27 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
| 10 mM | 0.20 mL | 1.01 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meibom BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 2024 PMID: 38348661
Product Specific Notices for BAY 9835
For research use only
Loading...
Loading...