BAY 876
Tocris Bioscience, part of Bio-Techne | Catalog # 6199
Potent and selective GLUT1 inhibitor
Key Product Details
Description
Potent and selective GLUT1 inhibitor
Product Description
BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.External Portal Information
The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.Product Specifications
Molecular Weight
496.42
Formula
C24H16F4N6O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
CAS Number
1799753-84-6
PubChem ID
118191391
InChI Key
BKLJDIJJOOQUFG-UHFFFAOYSA-N
SMILES
O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.64 | 100 |
Preparing Stock Solutions
for BAY 876
The following data is based on the product molecular weight 496.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.07 mL | 20.14 mL |
| 5 mM | 0.40 mL | 2.01 mL | 4.03 mL |
| 10 mM | 0.20 mL | 1.01 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ma Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers (Basel) 2018 PMID: 30602670
- Siebeneicher Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 2016 PMID: 27552707
Product Specific Notices for BAY 876
For research use only
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