BAY 707
Tocris Bioscience, part of Bio-Techne | Catalog # 6562
Potent and selective MTH1 inhibitor
Product Description
BAY 707 is a potent and selective MTH1 inhibitor (IC50 = 2.3 nM); exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. BAY 707 is cell-permeable and active in vivo, and displays no antitumor activity in vitro or in vivo.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-707 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 707 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
288.34
Formula
C15H20N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
CAS Number
2109805-96-9
PubChem ID
129012086
InChI Key
RPMGXDCRCWWCRY-JTQLQIEISA-N
SMILES
CCNC(C1=CC2=C(N3CCOC[C@@H]3C)C=CN=C2N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.83 | 100 | |
| Ethanol | 2.88 | 10 |
Preparing Stock Solutions
for BAY 707
The following data is based on the product molecular weight 288.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.34 mL | 34.68 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ellermann Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target. ACS Chem.Biol. 2017 PMID: 28679043
- Rahm Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design. J.Med.Chem. 2018 PMID: 29485874
Product Specific Notices for BAY 707
For research use only
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