BAY 678
Tocris Bioscience, part of Bio-Techne | Catalog # 5706
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
Key Product Details
Description
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
Product Description
BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 678 probe summary on the SGC website.Product Specifications
Molecular Weight
400.35
Formula
C20H15F3N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
CAS Number
675103-36-3
PubChem ID
23728722
InChI Key
PGIVGIFOWOVINL-GOSISDBHSA-N
SMILES
CC(C([C@H]1C2=CN=C(C#N)C=C2)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C(N1)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.03 | 100 |
Preparing Stock Solutions
for BAY 678
The following data is based on the product molecular weight 400.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.49 mL | 24.98 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- von Nussbaum Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. ChemMedChem. 2015 PMID: 26083237
Product Specific Notices for BAY 678
For research use only
Loading...
Loading...