BAY 60-6583

Tocris Bioscience, part of Bio-Techne | Catalog # 4472

Potent partial A2B agonist; cardioprotective
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Key Product Details

Description

Potent partial A2B agonist; cardioprotective

View all Adenosine A2b Receptor Agonists »

Product Description

BAY 60-6583 is a partial agonist at adenosine A2B receptors (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2A and A3 receptors. BAY 60-6583 antagonizes the effect of NECA (Cat. No. 1691) and adenosine (Cat. No. 3624) in cAMP accumulation assays. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

Product Specifications

Molecular Weight

379.44

Formula

C19H17N5O2S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide

CAS Number

910487-58-0

PubChem ID

11717831

InChI Key

ZTYHZMAZUWOXNC-UHFFFAOYSA-N

SMILES

NC1=NC(SCC(N)=O)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.94 100

Preparing Stock Solutions for BAY 60-6583

The following data is based on the product molecular weight 379.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for BAY 60-6583

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAY 60-6583

For research use only

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