BAY 1797
Tocris Bioscience, part of Bio-Techne | Catalog # 7573
Selective P2X4 antagonist
Product Description
BAY 1797 is a selective purinergic P2X4 receptor antagonist (IC50 values are 108, 112 and 233 nM for the human, mouse and rat P2X4, respectively). It is selective for P2X4 over P2X3, P2X7, and P2X1 receptors (IC50 values are 8.3, 10.6 and >50 μM, respectively, for the human receptors). BAY 1797 dose-dependently reduces prostaglandin E2 levels and exhibits anti-inflammatory and analgesic effects in an in vivo model of inflammatory pain. Orally active.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 1797 probe summary on the SGC website.Product Specifications
Molecular Weight
416.88
Formula
C20H17ClN2O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
CAS Number
2055602-83-8
PubChem ID
124125214
InChI Key
CSJYMAFXYMYNCK-UHFFFAOYSA-N
SMILES
NS(=O)(C1=C(C=CC(NC(CC2=CC=CC=C2)=O)=C1)OC3=CC(Cl)=CC=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.69 | 100 | |
| Ethanol | 41.69 | 100 |
Preparing Stock Solutions
for BAY 1797
The following data is based on the product molecular weight 416.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.80 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for BAY 1797
For research use only
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