BAY 091
Tocris Bioscience, part of Bio-Techne | Catalog # 7673
Potent and selective PIP4K2A inhibitor
Key Product Details
Description
Potent and selective PIP4K2A inhibitor
Product Description
BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC50 values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.Product Specifications
Molecular Weight
440.48
Formula
C26H21FN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-2-((3-Cyano-2-(2'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)-1,7-naphthyridin-4-yl)amino)butanoic acid
CAS Number
2922280-34-8
PubChem ID
155884467
InChI Key
DVIVLYHDLNAXAT-OAQYLSRUSA-N
SMILES
CC[C@H](C(O)=O)NC1=C(C(C2=CC=C(C3=C(C(C)=CC=C3)F)C=C2)=NC4=C1C=CN=C4)C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.02 | 50 with gentle warming |
Preparing Stock Solutions
for BAY 091
The following data is based on the product molecular weight 440.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.54 mL | 22.70 mL | 45.41 mL |
| 2.5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wortmann Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 2021 PMID: 34699202
Product Specific Notices for BAY 091
For research use only
Loading...
Loading...