Bax channel blocker
Tocris Bioscience, part of Bio-Techne | Catalog # 2160
Allosteric inhibitor of Bax channel activation
Key Product Details
Description
Allosteric inhibitor of Bax channel activation
Alternative Names
BAI1
Product Description
Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).Product Specifications
Molecular Weight
540.12
Formula
C19H21Br2N3O.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
CAS Number
329349-20-4
PubChem ID
2729026
InChI Key
HWFKCAFKXZFOQT-UHFFFAOYSA-N
SMILES
Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.34 | 5 | |
| DMSO | 46.72 | 100 |
Preparing Stock Solutions
for Bax channel blocker
The following data is based on the product molecular weight 540.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.26 mL | 18.51 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.70 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Garner Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol. 2019 PMID: 30718816
- Bombrun 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem.
Product Specific Notices for Bax channel blocker
For research use only
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