Batimastat is a potent, broad spectrum MMP inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

Product Specifications

Molecular Weight

477.64

Formula

C₂₃H₃₁N₃O₄S₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R,3S)-N⁴-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

CAS Number

130370-60-4

PubChem ID

5362422

InChI Key

XFILPEOLDIKJHX-QYZOEREBSA-N

SMILES

O=[C@]([C@H](CC(C)C)[C@@H]([C@](NO)=O)CSC2=CC=CS2)N[C@H](C(NC)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.76	100

Preparing Stock Solutions for Batimastat

The following data is based on the product molecular weight 477.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Background References

References are publications that support the biological activity of the product.

Wang Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 1994 PMID: 8062271
Kohn and Liotta Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 1995 PMID: 7728753
Davies A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 1993 PMID: 8347186

Batimastat

Tocris Bioscience, part of Bio-Techne | Catalog # 2961

Key Product Details

Description

Alternative Names

View all Matrix Metalloprotease (MMP) Inhibitors »

Product Description