BAM 15

Name: BAM 15
Brand: Tocris Bioscience
SKU: 5737
Price: 202 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 5737

Citations (2)

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Key Product Details

Description:	Mitochondrial protonophore uncoupler
Chemical Name:	N⁵,N⁶-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Purity:	≥98% (HPLC)
Molecular Weight:	340.29

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Biological Activity for BAM 15

BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC₅₀ = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

Compound Libraries for BAM 15

BAM 15 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAM 15

M. Wt	340.29
Formula	C₁₆H₁₀F₂N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	210302-17-3
PubChem ID	565708
InChi Key	OEGJBRZAJRPPHL-UHFFFAOYSA-N
Smiles	FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAM 15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.03	100

Preparing Stock Solutions for BAM 15

The following data is based on the product molecular weight 340.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.39 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for BAM 15

References are publications that support the biological activity of the product.

Axelrod BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. 2020 PMID: 32519812
Kenwood Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 2015 PMID: 26119501
Kenwood Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 2013 PMID: 24634817

Citations for BAM 15 (2)

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Citations are publications that use Bio-Techne products. Selected citations for BAM 15 include:

Styr et al. (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron. 102:1009
PMID: 31047779
Panja et al. (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol. 45:141
PMID: 29679372

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