Balicatib
Tocris Bioscience, part of Bio-Techne | Catalog # 5585
Potent and selective cathepsin K inhibitor
Key Product Details
Description
Potent and selective cathepsin K inhibitor
Product Description
Balicatib is a potent and selective cathepsin K inhibitor (IC50 values are 1.4, 56 and 480 nM for human, rat and mouse cathepsin K, respectively). Exhibits >300-fold selectivity for cathepsin K over cathepsins L, B and S. Long term supratherapeutic dosing increases tissue levels of cathepsins L and B in rats.Product Specifications
Molecular Weight
411.54
Formula
C23H33N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
CAS Number
354813-19-7
PubChem ID
10201696
InChI Key
LLCRBOWRJOUJAE-UHFFFAOYSA-N
SMILES
O=C(NC1(CCCCC1)C(NCC#N)=O)C(C=C2)=CC=C2N3CCN(CCC)CC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.15 | 100 |
Preparing Stock Solutions
for Balicatib
The following data is based on the product molecular weight 411.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.15 mL | 24.30 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Desmarais Effect of cathepsin k inhibitor basicity on in vivo off-target activities. Mol.Pharmacol. 2008 PMID: 17940194
Product Specific Notices for Balicatib
For research use only
Loading...
Loading...