Baicalein

Name: Baicalein
Brand: Tocris Bioscience
SKU: 1761

Tocris Bioscience a Bio-Techne Brand

Catalog # 1761

Citations (6)

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Key Product Details

Description:	5- and 12-Lipoxygenase inhibitor
Chemical Name:	5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.24

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Biological Activity for Baicalein

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC₅₀ values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G₁ and G₂ cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.

Technical Data for Baicalein

M. Wt	270.24
Formula	C₁₅H₁₀O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	491-67-8
PubChem ID	5281605
InChi Key	FXNFHKRTJBSTCS-UHFFFAOYSA-N
Smiles	OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Baicalein

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	13.51	50

Preparing Stock Solutions for Baicalein

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.40 mL	37.00 mL	74.01 mL
2.5 mM	1.48 mL	7.40 mL	14.80 mL
5 mM	0.74 mL	3.70 mL	7.40 mL
25 mM	0.15 mL	0.74 mL	1.48 mL

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References for Baicalein

References are publications that support the biological activity of the product.

Xie Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 2016 PMID: 27037021
Hsieh Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 2007 PMID: 18039391
Nakahata Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 2003 PMID: 12568909
Hsu Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 2001 PMID: 11513834
Sekiya and Okuda Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 1982 PMID: 6807310

Citations for Baicalein (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Baicalein include:

Oguh-Olayinka et al. (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;
PMID: 30941737
Mishra et al. (2017) Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol. 2:17072
PMID: 28504669
Maskrey et al. (2014) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. PLoS One. 11:33
PMID: 25349537
Potapova et al. (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS One. 8:e73929
PMID: 24069252
Starowicz et al. (2013) Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS One. 8:e60040
PMID: 23573230
Gibson et al. (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 57:746
PMID: 18341994

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