Baicalein

Name: Baicalein
Brand: Tocris Bioscience
SKU: 1761

Tocris Bioscience, part of Bio-Techne | Catalog # 1761

Citations (5)

COA / SDS

5- and 12-Lipoxygenase inhibitor

Discontinued Product

1761 has been discontinued. View all Lipoxygenase Inhibitors products.

Key Product Details

Description:	5- and 12-Lipoxygenase inhibitor
Chemical Name:	5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.24

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Technical Data
Citations

Biological Activity for Baicalein

Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC₅₀ values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G₁ and G₂ cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.

Technical Data for Baicalein

M. Wt	270.24
Formula	C₁₅H₁₀O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	491-67-8
PubChem ID	5281605
InChi Key	FXNFHKRTJBSTCS-UHFFFAOYSA-N
Smiles	OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Baicalein

References are publications that support the biological activity of the product.

Xie Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 2016 PMID: 27037021
Hsieh Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 2007 PMID: 18039391
Nakahata Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 2003 PMID: 12568909
Sekiya and Okuda Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 1982 PMID: 6807310
Hsu Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 2001 PMID: 11513834

Baicalein

Tocris Bioscience, part of Bio-Techne | Catalog # 1761

Key Product Details

Biological Activity for Baicalein

Technical Data for Baicalein

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Baicalein

Product Documents for Baicalein

COA

Certificate of Analysis

SDS

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