AZD 9291
Tocris Bioscience, part of Bio-Techne | Catalog # 8873
Potent mutant-selective EGFR inhibitor
Key Product Details
Description
Potent mutant-selective EGFR inhibitor
Product Description
AZD 9291 is a potent mutant-selective EGFR inhibitor (IC50 values are 1 and 12 nM against EGFR mutants L858R/T790M and L858R, respectively). AZD 9291 exhibited nearly 200 times greater potency against L858R/T790M than wild-type EGFR. In vivo, AZD 9291 causes tumor regression in mutant EGFR xenograft models of non-small cell lung cancer (NSCLC) and transgenic mutant T790M EGFR disease models. AZD 9291 is orally bioavailable.Product Specifications
Molecular Weight
499.61
Formula
C28H33N7O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
CAS Number
1421373-65-0
PubChem ID
71496458
InChI Key
DUYJMQONPNNFPI-UHFFFAOYSA-N
SMILES
O=C(C=C)NC1=CC(NC=2N=CC=C(N2)C3=CN(C=4C=CC=CC34)C)=C(OC)C=C1N(C)CCN(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.98 | 50 | |
| Ethanol | 9.99 | 20 |
Preparing Stock Solutions
for AZD 9291
The following data is based on the product molecular weight 499.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.00 mL | 20.02 mL | 40.03 mL |
| 2.5 mM | 0.80 mL | 4.00 mL | 8.01 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cross AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 PMID: 24893891
Product Specific Notices for AZD 9291
For research use only
Loading...
Loading...