AZD 3988

Name: AZD 3988
Brand: Tocris Bioscience
SKU: 4837

Tocris Bioscience, part of Bio-Techne | Catalog # 4837

Citations (14)

COA / SDS

Potent and selective DGAT-1 inhibitor

Key Product Details

Description:	Potent and selective DGAT-1 inhibitor
Chemical Name:	trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	456.44

View Full Technical Details for AZD 3988

Technical Data
Citations

Biological Activity for AZD 3988

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC₅₀ = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, K_v11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZD 3988

AZD 3988 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZD 3988

M. Wt	456.44
Formula	C₂₃H₂₂F₂N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	892489-52-0
PubChem ID	23648867
InChi Key	NGEBYTLALFOQKI-UHFFFAOYSA-N
Smiles	O=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 3988

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.64	100
	1eq. NaOH	4.56	10 with gentle warming

Preparing Stock Solutions for AZD 3988

The following data is based on the product molecular weight 456.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.91 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for AZD 3988

References are publications that support the biological activity of the product.

McCoull Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 2012 PMID: 22608962