AZD 3988
Tocris Bioscience, part of Bio-Techne | Catalog # 4837
Potent and selective DGAT-1 inhibitor
Key Product Details
Description
Potent and selective DGAT-1 inhibitor
Product Description
AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
456.44
Formula
C23H22F2N4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
CAS Number
892489-52-0
PubChem ID
23648867
InChI Key
NGEBYTLALFOQKI-UHFFFAOYSA-N
SMILES
O=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.64 | 100 | |
| 1eq. NaOH | 4.56 | 10 with gentle warming |
Preparing Stock Solutions
for AZD 3988
The following data is based on the product molecular weight 456.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.95 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McCoull Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 2012 PMID: 22608962
Product Specific Notices for AZD 3988
For research use only
Loading...
Loading...