AZD 2858

Tocris Bioscience, part of Bio-Techne | Catalog # 7650

Highly potent GSK-3 inhibitor; inhibits tau phosphorylation
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Key Product Details

Description

Highly potent GSK-3 inhibitor; inhibits tau phosphorylation

View all Glycogen Synthase Kinase Substrates »

Product Description

AZD 2858 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 0.9 and 5 nM for GSK-3α and GSK-3β, respectively). AZD 2858 inhibits tau phosphorylation in vitro (IC50 = 76 nM), improves fracture healing and increases bone mass in rodent models of bone fracture. Also activates Wnt signaling in vitro and in vivo. Brain permeable and orally bioavailable.

Product Specifications

Molecular Weight

453.52

Formula

C21H23N7O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide

CAS Number

486424-20-8

PubChem ID

10138980

InChI Key

FHCSBLWRGCOVPT-UHFFFAOYSA-N

SMILES

O=C(NC=1C=NC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)N4CCN(C)CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.54 10

Preparing Stock Solutions for AZD 2858

The following data is based on the product molecular weight 453.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.25 mL 220.50 mL
0.5 mM 4.41 mL 22.05 mL 44.10 mL
1 mM 2.20 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.20 mL 4.41 mL

Calculators

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Product Documents for AZD 2858

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZD 2858

For research use only

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