AZD 2098

Tocris Bioscience, part of Bio-Techne | Catalog # 6541

Potent and selective CCR4 antagonist
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Key Product Details

Description

Potent and selective CCR4 antagonist

View all Chemokine CC Receptor Antagonists »

Product Description

AZD 2098 is a potent and selective CCR4 antagonist (pIC50 = 7.8). Exhibits no activity at CXCR1 and CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 at 10 μM, and no significant activity when screened against a panel of 120 receptors and enzymes. Inhibits CCL22 Ca2+ response and Th2 cell CCL17/22 driven chemotaxis in vitro. Inhibits lung inflammation following antigen challenge in ovalbumin- sensitized rats.

Product Specifications

Molecular Weight

334.18

Formula

C11H9Cl2N3O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide

CAS Number

566203-88-1

PubChem ID

10308720

InChI Key

FLSMVCMSUNISFK-UHFFFAOYSA-N

SMILES

COC1=NC=CN=C1NS(=O)(C2=C(Cl)C(Cl)=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.42 100
Ethanol 3.34 10

Preparing Stock Solutions for AZD 2098

The following data is based on the product molecular weight 334.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.92 mL
5 mM 0.60 mL 2.99 mL 5.98 mL
10 mM 0.30 mL 1.50 mL 2.99 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AZD 2098

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZD 2098

For research use only

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