AZD 1283
Tocris Bioscience, part of Bio-Techne | Catalog # 6085
High affinity P2Y12 antagonist
Product Description
AZD 1283 is a potent and high affinity P2Y12 antagonist (IC50 = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.Product Specifications
Molecular Weight
470.54
Formula
C23H26N4O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
CAS Number
919351-41-0
PubChem ID
23649325
InChI Key
NEMHKCNXXRQYRF-UHFFFAOYSA-N
SMILES
CCOC(C1=CC(C#N)=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)N=C1C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.05 | 100 |
Preparing Stock Solutions
for AZD 1283
The following data is based on the product molecular weight 470.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Agonist-bound structure of the human P2Y12 receptor. Nature 2014 PMID: 24784220
- Zhang Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 2014 PMID: 24670650
- Bach Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 2013 PMID: 23899349
Product Specific Notices for AZD 1283
For research use only
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