AZD 1208

Product Description

AZD 1208 is a potent pan Pim kinase inhibitor (IC₅₀ values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.

Solubility

Preparing Stock Solutions for AZD 1208

The following data is based on the product molecular weight 379.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.18 mL	65.88 mL	131.76 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
2 mM	1.32 mL	6.59 mL	13.18 mL
10 mM	0.26 mL	1.32 mL	2.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Salazar Targeting host PIM protein kinases reduces Mayaro virus replication. Viruses 2022 PMID: 35216015
• Brasó-Maristany PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat.Med. 2016 PMID: 27775704
• Dakin Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg.Med.Chem.Lett. 2012 PMID: 22727640
• Keeton AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood 2014 PMID: 24363397