AZ PFKFB3 67
Tocris Bioscience, part of Bio-Techne | Catalog # 5742
Potent and selective PFKFB3 inhibitor
Product Description
AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).Product Specifications
Molecular Weight
455.51
Formula
C26H25N5O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
CAS Number
1704741-11-6
PubChem ID
91668554
InChI Key
NDIKFKQBWGMLCA-DEOSSOPVSA-N
SMILES
N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.55 | 100 | |
| Ethanol | 45.55 | 100 |
Preparing Stock Solutions
for AZ PFKFB3 67
The following data is based on the product molecular weight 455.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 10.98 mL | 21.95 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762
Product Specific Notices for AZ PFKFB3 67
For research use only
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