AZ 3246 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8973
Potent and selective MAP4K1 (HPK1) inhibitor
Key Product Details
Description
Potent and selective MAP4K1 (HPK1) inhibitor
Product Description
AZ 3246 is a potent and selective hematopoietic progenitor kinase 1 (HPK1) inhibitor (HPK1 ADP-Glo IC50 < 3 nM; IL2 EC50 = 110 nM). Displays selectivity over a panel of 357 kinases in biochemical assays and over STK3, STK4 and TNIK in proteomic experiments on cell lysates. Induces IL2 secretion in T-cells and displays tumour growth inhibition in EMT6 mouse model. Orally bioavailable.Product Specifications
Molecular Weight
471.45
Formula
C21H20F3N9O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-Cyclopropyl-6-(3-methyl-3H-imidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-2-pyrazinecarboxamide
CAS Number
2893978-54-4
PubChem ID
166485054
InChI Key
YLGMPWWMPCGYBF-UHFFFAOYSA-N
SMILES
O=C(N)C1=NC(C2=CN=CC3=C2N=CN3C)=C(N=C1NC4=CN(N=C4C)CC(F)(F)F)C5CC5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.57 | 50 with gentle warming |
Preparing Stock Solutions
for AZ 3246
The following data is based on the product molecular weight 471.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.24 mL | 21.21 mL | 42.42 mL |
| 2.5 mM | 0.85 mL | 4.24 mL | 8.48 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shields Discovery and optimization of pyrazine carboxamide AZ3246, a selective HPK1 inhibitor. J.Med.Chem
Product Specific Notices for AZ 3246
For research use only
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