AZ 11645373
Tocris Bioscience, part of Bio-Techne | Catalog # 3317
Potent and selective human P2X7 antagonist
Key Product Details
Description
Potent and selective human P2X7 antagonist
Product Description
AZ 11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (KB values are 15 and 92 nM respectively).Licensing Information
Sold for research purposes under agreement from AstraZenecaProduct Specifications
Molecular Weight
463.51
Formula
C24H21N3O5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
CAS Number
227088-94-0
PubChem ID
9804433
InChI Key
VQEHBLGYANQWEA-UHFFFAOYSA-N
SMILES
O=C(CSC4=O)N4C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC1=CC=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.64 | 10 |
Preparing Stock Solutions
for AZ 11645373
The following data is based on the product molecular weight 463.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.57 mL | 107.87 mL | 215.75 mL |
| 0.5 mM | 4.31 mL | 21.57 mL | 43.15 mL |
| 1 mM | 2.16 mL | 10.79 mL | 21.57 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Michel Mechanism of action of species-selective P2X(7) receptor antagonists. Br.J.Pharmacol. 2009 PMID: 19309360
- Alcaraz Novel P2X7 receptor antagonists. Bioorg.Med.Chem.Letts.
- Stokes Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373. Br.J.Pharmacol. 2006 PMID: 17031385
Product Specific Notices for AZ 11645373
For research use only
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