AZ 10606120 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3323

Potent P2X7 antagonist
Catalog #
Availability
Size / Price
Qty
3323/10
3323/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Potent P2X7 antagonist

View all P2X Receptor Antagonists »

Product Description

AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist (KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Product Specifications

Molecular Weight

495.48

Formula

C25H34N4O2.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

CAS Number

607378-18-7

PubChem ID

56972227

InChI Key

BVFONFUUWORSPO-UHFFFAOYSA-N

SMILES

O=C(NC4=C(C=CC(NCCNCCO)=N5)C5=CC=C4)CC1(C3)CC2CC(CC3C2)C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 12.39 25
DMSO 49.55 100

Preparing Stock Solutions for AZ 10606120 dihydrochloride

The following data is based on the product molecular weight 495.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.40 mL 2.02 mL 4.04 mL
10 mM 0.20 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for AZ 10606120 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ 10606120 dihydrochloride

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.