AZ 10606120 dihydrochloride

Name: AZ 10606120 dihydrochloride
Brand: Tocris Bioscience
SKU: 3323

Tocris Bioscience, part of Bio-Techne | Catalog # 3323

Citations (11)

COA / SDS

Potent P2X7 antagonist

Key Product Details

Description:	Potent P2X₇ antagonist
Chemical Name:	N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	495.48

View Full Technical Details for AZ 10606120 dihydrochloride

Technical Data
Citations

Biological Activity for AZ 10606120 dihydrochloride

AZ 10606120 dihydrochloride is a potent P2X₇ receptor antagonist (K_D values are 1.4 and 19 nM at human and rat P2X₇ receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries for AZ 10606120 dihydrochloride

AZ 10606120 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZ 10606120 dihydrochloride

M. Wt	495.48
Formula	C₂₅H₃₄N₄O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	607378-18-7
PubChem ID	56972227
InChi Key	BVFONFUUWORSPO-UHFFFAOYSA-N
Smiles	O=C(NC4=C(C=CC(NCCNCCO)=N5)C5=CC=C4)CC1(C3)CC2CC(CC3C2)C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 10606120 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	12.39	25
	DMSO	49.55	100

Preparing Stock Solutions for AZ 10606120 dihydrochloride

The following data is based on the product molecular weight 495.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for AZ 10606120 dihydrochloride

References are publications that support the biological activity of the product.

Adinolfi Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012 PMID: 22505653
Michel and Fonfria Agonist potency at P2X₇ receptors is modulated by structurally diverse lipids. Br.J.Pharmacol. 2007 PMID: 17700717
Michel Negative and positive allosteric modulators of the P2X₇ receptor. Br.J.Pharmacol. 2008 PMID: 18071294
Michel Direct labelling of the human P2X₇ receptor and identification of positive and negative cooperativity of binding. Br.J.Pharmacol. 2007 PMID: 17339830