AZ 10606120 dihydrochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Potent P2X7 antagonist |
Chemical Name: | N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 495.48 |
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Citations for AZ 10606120 dihydrochloride (15)
Citations are publications that use Bio-Techne products. Selected citations for AZ 10606120 dihydrochloride include:
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Palygin et al.
(2018)
Characterization of purinergic receptor expression in ARPKD cystic epithelia.
Purinergic Signal.
14:485
PMID: 30417216 -
Allsopp
(2017)
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
Sci Rep.
7(1)
PMID: 28389651 -
Karmakar et al.
(2016)
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
Nat.Commun..
7:10555
PMID: 26877061 -
Russo et al.
(2016)
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
The Journal of Immunology.
197:1353
PMID: 27385778 -
Kowal et al.
(2015)
Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
Mol Cancer.
13:28
PMID: 26050734 -
Giannuzzo et al.
(2015)
The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.
Purinergic Signal.
14:203
PMID: 26607222 -
Helliwell et al.
(2015)
Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
Br J Pharmacol.
172:3326
PMID: 25752193 -
Martin et al.
(2014)
IKKα negatively regulates ASC-dependent inflammasome activation.
Nat Commun.
5:4977
PMID: 25266676 -
Bhaskaracharya et al.
(2014)
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
PLoS One.
9:e93058
PMID: 24671093 -
Kaiser et al.
(2014)
Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
J Pharmacol Exp Ther.
350:531
PMID: 24970925 -
Fischer et al.
(2013)
Natural compounds with P2X7 receptor-modulating properties.
Purinergic Signal.
10:313
PMID: 24163006 -
Nörenberg et al.
(2012)
Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
Br J Pharmacol.
167:48
PMID: 22506590 -
Heinrich et al.
(2012)
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
Br J Pharmacol.
167:1003
PMID: 22394324 -
Gadeock et al.
(2012)
P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
Mol Biol Cell.
8:669
PMID: 22661222 -
Hracskó et al.
(2011)
Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease.
Mol Neurodegener.
6:28
PMID: 21542899
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