AY 9944 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1639

Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase
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Key Product Details

Description

Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase

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Product Description

AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

Product Specifications

Molecular Weight

464.30

Formula

C22H28Cl2N2.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

CAS Number

366-93-8

PubChem ID

9954082

InChI Key

GZFYZYBWLCYBMI-MYZJJQSMSA-N

SMILES

ClC(C=CC=C3)=C3CNC[C@H]1CC[C@H](CNCC2=C(Cl)C=CC=C2)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.21 50
DMSO 2.32 5

Preparing Stock Solutions for AY 9944 dihydrochloride

The following data is based on the product molecular weight 464.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.31 mL 21.54 mL 43.08 mL
2.5 mM 0.86 mL 4.31 mL 8.62 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for AY 9944 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AY 9944 dihydrochloride

For research use only

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