Autophinib

Name: Autophinib
Brand: Tocris Bioscience
SKU: 6324

Tocris Bioscience, part of Bio-Techne | Catalog # 6324

Citations (4)

COA / SDS

Potent VPS34 inhibitor

Key Product Details

Description:	Potent VPS34 inhibitor
Chemical Name:	6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	346.73

View Full Technical Details for Autophinib

Technical Data
Citations

Biological Activity for Autophinib

Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC₅₀ = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC₅₀ values = 40 and 90 nM, respectively).

Compound Libraries for Autophinib

Autophinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Autophinib

M. Wt	346.73
Formula	C₁₄H₁₁ClN₆O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1644443-47-9
PubChem ID	129626605
InChi Key	CEUMAXLRGBKFQP-UHFFFAOYSA-N
Smiles	CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Autophinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.93	20

Preparing Stock Solutions for Autophinib

The following data is based on the product molecular weight 346.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.42 mL	72.10 mL	144.20 mL
1 mM	2.88 mL	14.42 mL	28.84 mL
2 mM	1.44 mL	7.21 mL	14.42 mL
10 mM	0.29 mL	1.44 mL	2.88 mL

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Reconstitution Calculator

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References for Autophinib

References are publications that support the biological activity of the product.

Robke Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28544137
Richters Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 2015 PMID: 25540906