AUNP 12

Name: AUNP 12
Brand: Tocris Bioscience
SKU: 7831

Tocris Bioscience, part of Bio-Techne | Catalog # 7831

COA / SDS

Peptide inhibitor of the PD-1 signaling pathway

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Product Description
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Background References
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Key Product Details

Description

Peptide inhibitor of the PD-1 signaling pathway

View all Immune Checkpoint Inhibitors »

Product Description

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC₅₀ values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC₅₀ values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

Product Specifications

Molecular Weight

3261.56

Formula

C₁₄₂H₂₂₆N₄₀O₄₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1353563-85-5

PubChem ID

154701623

InChI Key

ZBJUUYIGBAQYBN-QKLNNLIKSA-N

SMILES

OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)=O)=O)=O)CCCCNC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC(N)=O)NC([C@H](CO)N)=O)=O)=O)=O)CCC(O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)CCC(N)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Sasikumar A rationally designed peptide antagonist of the PD-1 signaling pathway as an immunomodulatory agent for cancer therapy. Mol.Cancer Ther. 2019 PMID: 31015307
Zhan From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway. Drug Discov.Today 2016 PMID: 27094104
Omstead CSF-1R inhibitor, pexidartinib, sensitizes esophageal adenocarcinoma to PD-1 immune checkpoint blockade in a rat model. Carcinogenesis 2022 PMID: 35552655