AUNP 12

Name: AUNP 12
Brand: Tocris Bioscience
SKU: 7831

Tocris Bioscience, part of Bio-Techne | Catalog # 7831

COA / SDS

Peptide inhibitor of the PD-1 signaling pathway

Key Product Details

Description:	Peptide inhibitor of the PD-1 signaling pathway
Purity:	≥95% (HPLC)
Molecular Weight:	3261.56

View Full Technical Details for AUNP 12

Technical Data
Citations

Biological Activity for AUNP 12

AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC₅₀ values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC₅₀ values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).

Technical Data for AUNP 12

M. Wt	3261.56
Formula	C₁₄₂H₂₂₆N₄₀O₄₈
Single Letter Sequence	SNTSESFKFRVTQLAPKAQIKE SNTSESF* (Modifications: Amide bridge= 8-7*, Glu-22 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1353563-85-5
PubChem ID	154701623
InChi Key	ZBJUUYIGBAQYBN-QKLNNLIKSA-N
Smiles	OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)=O)=O)=O)CCCCNC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC(N)=O)NC([C@H](CO)N)=O)=O)=O)=O)CCC(O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)CCC(N)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AUNP 12

Solubility

Soluble to 2mg/ml in water

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References for AUNP 12

References are publications that support the biological activity of the product.

Sasikumar A rationally designed peptide antagonist of the PD-1 signaling pathway as an immunomodulatory agent for cancer therapy. Mol.Cancer Ther. 2019 PMID: 31015307
Zhan From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway. Drug Discov.Today 2016 PMID: 27094104
Omstead CSF-1R inhibitor, pexidartinib, sensitizes esophageal adenocarcinoma to PD-1 immune checkpoint blockade in a rat model. Carcinogenesis 2022 PMID: 35552655