ATI 2341

Name: ATI 2341
Brand: Tocris Bioscience
SKU: 5795

Tocris Bioscience, part of Bio-Techne | Catalog # 5795

Citations (2)

COA / SDS

CXCR4 allosteric agonist

Key Product Details

Description:	CXCR4 allosteric agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2256.82

View Full Technical Details for ATI 2341

Technical Data
Citations

Biological Activity for ATI 2341

ATI 2341 is a CXCR4 allosteric agonist (EC₅₀ = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards G_i proteins over G₁₃ and β-arrestin.

Technical Data for ATI 2341

M. Wt	2256.82
Formula	C₁₀₄H₁₇₈N₂₆O₂₅S₂
Single Letter Sequence	MGYQKKLRSMTDKYRL (Modification: Met-1 = N-terminal Palmitoyl)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1337878-62-2
PubChem ID	101961246
InChi Key	YMLOFEANRZSEGQ-QNHYGVTPSA-N
Smiles	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ATI 2341

Solubility

Soluble to 1mg/ml in water

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References for ATI 2341

References are publications that support the biological activity of the product.

Planesas Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 2015 PMID: 26080355
Quoyer Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 24309376
Tchernychev Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 21139054