Astressin 2B

Name: Astressin 2B
Brand: Tocris Bioscience
SKU: 2391

Tocris Bioscience, part of Bio-Techne | Catalog # 2391

Citations (37)

COA / SDS

Selective CRF2 antagonist

Key Product Details

Description:	Selective CRF₂ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	4041.69

View Full Technical Details for Astressin 2B

Technical Data
Citations

Biological Activity for Astressin 2B

Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF₂) antagonist (IC₅₀ values are 1.3 and > 500 nM for CRF₂ and CRF₁ respectively). Antagonizes CRF₂-mediated inhibition of gastric emptying.

Technical Data for Astressin 2B

M. Wt	4041.69
Formula	C₁₈₃H₃₀₇N₄₉O₅₃
Single Letter Sequence	DLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI (Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Ile-33 = C-terminal amide, Lactam Bridge: Glu-24 - L
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	681260-70-8
PubChem ID	90488758
InChi Key	IVIBPRHVUKMKSX-YJHXGIRISA-N
Smiles	CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](C)(CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Astressin 2B

Solubility

Soluble to 1mg/ml in water

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References for Astressin 2B

References are publications that support the biological activity of the product.

Hoare Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupled sensitivity and determinants of CRF2 receptor selectivity. Peptides 2005 PMID: 15652653
Henry The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J.Neurosci. 2006 PMID: 16957071
Rivier Potent and long-acting cortico. releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J.Med.Chem. 2002 PMID: 12361401