AS2717638

Tocris Bioscience, part of Bio-Techne | Catalog # 7730

Selective, brain penetrant LPA5 antagonist
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Key Product Details

Description

Selective, brain penetrant LPA5 antagonist

View all Lysophosphatidic Acid (LPA) Receptor Antagonists »

Product Description

AS2717638 is a potent LPA5 receptor antagonist (IC50 = 38 nM in BV-2 microglia cells). It is selective for LPA5 over LPA1, LPA2, and LPA3. It inhibits LPA-mediated pro-inflammatory transcription factor phosphorylation. In vivo, AS2717638 inhibits LPA5 agonist-induced allodynia in mice. It also exhibits analgesic effects against both neuropathic and inflammatory pain in rodent models. Orally bioavailable and brain penetrant.

Product Specifications

Molecular Weight

447.48

Formula

C25H25N3O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6,7-Dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone

CAS Number

2148339-28-8

PubChem ID

137333453

InChI Key

QRMYHYZQUGJBBX-UHFFFAOYSA-N

SMILES

O=C1C=2C=C(OC)C(OC)=CC2C(=CN1C3=NOC=4C=CC(=CC43)C)C(=O)N5CCCCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.47 10

Preparing Stock Solutions for AS2717638

The following data is based on the product molecular weight 447.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.74 mL 223.47 mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

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Product Documents for AS2717638

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AS2717638

For research use only

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