ARL 67156 trisodium salt is a selective NTPDase inhibitor (pIC₅₀ = 4.62 and 5.1 in human blood and rat vas deferens respectively). ARL 67156 prevents vascular calcification and extends longevity in Hutchinson-Gilford progeria syndrome mice. ARL 67156 increases neurogenic contract response to nerve stimulation. ARL 67156 enhances parasympathetic neurotransmission in guinea-pig urinary bladder.

Product Specifications

Molecular Weight

785.06

Formula

C₁₅H₂₁Br₂N₅O₁₂P₃.3Na

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt

CAS Number

1021868-83-6

PubChem ID

52948496

InChI Key

KJYSFRKUFDOOSQ-ZANJJFDZSA-K

SMILES

O[C@H]3[C@H](O)[C@@H](O[C@@H]3COP(OP(C(Br)(Br)P(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)N1C=NC2=C1N=CN=C2N(CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.78	20

Preparing Stock Solutions for ARL 67156 trisodium salt

The following data is based on the product molecular weight 785.06

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.37 mL	31.84 mL	63.69 mL
1 mM	1.27 mL	6.37 mL	12.74 mL
2 mM	0.64 mL	3.18 mL	6.37 mL
10 mM	0.13 mL	0.64 mL	1.27 mL

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Background References

References are publications that support the biological activity of the product.

Villa-Bellosta ATP-based therapy prevents vascular calcification and extends longevity in a mouse model of Hutchinson-Gilford progeria syndrome. Proc.Natl.Acad.Sci.U.S.A. 2019 PMID: 31690656
Westfall The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea pig urinary bladder. Eur.J.Pharmacol. 1997 PMID: 9226410
Kennedy Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation? TiPS 1997 PMID: 9277128
Levesque Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ecotnucleotidases. Br.J.Pharmacol. 2007 PMID: 17603550
Crack Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br.J.Pharmacol. 1995 PMID: 7533620

ARL 67156 trisodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 1283

Key Product Details

Description

Alternative Names

View all NTPDase Inhibitors »

Product Description