Argatroban
Tocris Bioscience, part of Bio-Techne | Catalog # 1637
Potent thrombin inhibitor
Key Product Details
Description
Potent thrombin inhibitor
Product Description
Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.This compound is a mixture of 2 diastereomers (approximate ratio 65/35).
Product Specifications
Molecular Weight
508.63
Formula
C23H36N6O5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
CAS Number
74863-84-6
PubChem ID
6604954
InChI Key
CQTDZUSQSTUZDA-UHFFFAOYSA-M
SMILES
O=C(N1[C@@H]([C@@](O)=O)C[C@H](C)CC1)[C@@H](NS(C2=CC=CC3=C2NCC(C)C3)(=O)=O)CCCNC(N)=N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 5.09 | 10 | |
| DMSO | 50.86 | 100 |
Preparing Stock Solutions
for Argatroban
The following data is based on the product molecular weight 508.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 10 mM | 0.20 mL | 0.98 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jang Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 1990 PMID: 2297828
- Fitzgerald and Fitzgerald Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA
- Kikumoto Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 1984 PMID: 6691968
Product Specific Notices for Argatroban
For research use only
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