ARCC 4 negative control

Name: ARCC 4 negative control
Brand: Tocris Bioscience
SKU: 7255
Price: 406 USD

Catalog # 7255 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Negative control for ARCC 4 (Cat. No. 7254)

Key Product Details

Description:	Negative control for ARCC 4 (Cat. No. 7254)
Chemical Name:	(2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1024.18

View Full Technical Details for ARCC 4 negative control

Biological Activity for ARCC 4 negative control

ARCC 4 negative control is a negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.

Technical Data for ARCC 4 negative control

M. Wt	1024.18
Formula	C₅₃H₅₆F₃N₇O₇S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2156588-26-8
PubChem ID	145746289
InChi Key	DUPAJELXESPTNF-RNEKHSKBSA-N
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARCC 4 negative control

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	102.42	100

Preparing Stock Solutions for ARCC 4 negative control

The following data is based on the product molecular weight 1024.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.98 mL	4.88 mL	9.76 mL
5 mM	0.20 mL	0.98 mL	1.95 mL
10 mM	0.10 mL	0.49 mL	0.98 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for ARCC 4 negative control

References are publications that support the biological activity of the product.

Salami Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 2018 PMID: 30271980

Citations for ARCC 4 negative control

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ARCC 4 negative control

Catalog # 7255 | Tocris Bioscience a Bio-Techne Brand

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Biological Activity for ARCC 4 negative control

Technical Data for ARCC 4 negative control

Solubility for ARCC 4 negative control

Preparing Stock Solutions for ARCC 4 negative control

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ARCC 4 negative control

Citations for ARCC 4 negative control

Product Documents for ARCC 4 negative control

COA

Certificate of Analysis

SDS

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