ARC 239 dihydrochloride

Name: ARC 239 dihydrochloride
Brand: Tocris Bioscience
SKU: 0928

Catalog # 0928

Citations (1)

COA / SDS

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$35 to United States

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Key Product Details

Description:	α_2B antagonist
Chemical Name:	2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	480.43

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Biological Activity

ARC 239 dihydrochloride is a selective α_2B adrenoceptor antagonist (pK_D values are 8.8, 6.7 and 6.4 at α_2B, α_2A, and α_2D receptors respectively).

Licensing Information

Sold with the permission of Boehringer Ingelheim GmbH

Technical Data

M. Wt	480.43
Formula	C₂₄H₂₉N₃O₃.2HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	55974-42-0
PubChem ID	10345075
InChi Key	SAJKHRHHDGSJEZ-UHFFFAOYSA-N
Smiles	Cl.Cl.COC1=CC=CC=C1N1CCN(CCN2C(=O)C3=C(C=CC=C3)C(C)(C)C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	48.04	100

Preparing Stock Solutions

The following data is based on the product molecular weight 480.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.81 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References

References are publications that support the biological activity of the product.

Fuder and Selback Characterisation of sensory neurotransmission and its inhibition via α_2B-adrenoceptors and via non-α₂ adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 7685502
Bylund Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 1988 PMID: 2835476

Citations for ARC 239 dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for ARC 239 dihydrochloride include:

Kahn et al. (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 8:511
PMID: 27138566

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