ARC 239 dihydrochloride

Name: ARC 239 dihydrochloride
Brand: tocris
SKU: 0928

Catalog # 0928

Citations (1)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	α_2B antagonist
Chemical Name:	2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	480.43

View Full Technical Details for ARC 239 dihydrochloride

Biological Activity

Selective α_2B adrenoceptor antagonist (pK_D values are 8.8, 6.7 and 6.4 at α_2B, α_2A, and α_2D receptors respectively). Also available as part of the α₂-Adrenoceptor Tocriset™.

Licensing Information

Sold with the permission of Boehringer Ingelheim GmbH

Technical Data

M. Wt	480.43
Formula	C₂₄H₂₉N₃O₃.2HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	55974-42-0
PubChem ID	10345075
InChi Key	SAJKHRHHDGSJEZ-UHFFFAOYSA-N
Smiles	Cl.Cl.COC1=CC=CC=C1N1CCN(CCN2C(=O)C3=C(C=CC=C3)C(C)(C)C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	48.04	100

Preparing Stock Solutions

The following data is based on the product molecular weight 480.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.81 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Bylund Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype. J.Pharmacol.Exp.Ther. 1988 PMID: 2835476
Fuder and Selback Characterisation of sensory neurotransmission and its inhibition via α_2B-adrenoceptors and via non-α₂ adrenoceptors in rabbit iris. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 7685502

Citations (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for ARC 239 dihydrochloride include:

Kahn et al. (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 8:511
PMID: 27138566

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

ARC 239 dihydrochloride

Order Information

Shipping Information

Key Product Details

Complete Your Experiment

Biological Activity

Licensing Information

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected