APE1 Redox Inhibitor

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49581

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Product Summary for APE1 Redox Inhibitor

E3330 Chemical Information:
Synonym: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
Molecular Weight: 378.459
Empirical Formula: C21H30O6
CAS Number: 136164-66-4
HPLC purity is >= to 97%
Solubility: DMSO: >20 mg/mL
Form: powder
Color: orange

Product Specifications

Specificity

E3330 is a chemical that inhibits the redox activity of APE1.

Clone

E3330

Application Notes

E3330 is useful for inhibiting APE1 redox activity.

Scientific Data Images for APE1 Redox Inhibitor

APE1 Redox Inhibitor [NBP1-49581] - Chemical Structure of E3330 [NBP1-49581]

Formulation, Preparation, and Storage

Formulation

This product is supplied as a powder. It is soluble in DMSO (>20 mg/mL).

Concentration

Concentration is not relevant for this product. Please see the protocols for proper use of this product.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: APE1 Redox

E3330 represents a novel class of inhibitor. Unlike other compounds that target APE1, it has been recently reported that E3330 recognizes an alternate, redox active conformation of APE1, and that it potentially inhibits APE1's redox activity by inducing disulfide bond formation. No other compound has been reported to selectively recognize an alternate conformation of APE1 or work through this type of mechanism. Thus, E3330 represents a novel class of inhibitor. E3330 was originally developed as an NFkB inhibitor, but subsequently APE1 was found to bind to E3330 through affinity pull-down experiments using immobilized E3330. In light of later work demonstrating that APE1 regulates the transcriptional activity of NFkB, we now know that E3330 actually works upstream of NFkB by inhibiting APE1. Although many quinone compounds have undesirable properties including susceptibility to Michael additions by nucleophiles, E3330 does not form covalent adducts with APE1 because there is no substituent that can serve as an effective leaving group.

Alternate Names

(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid, 3330, AP endonuclease 1 Inhibitor, APE-1 Inhibitor, APEX 1 Inhibitor, Apurinic Endonuclase Factor 1 Inhibitor, APX3330, E-3330, REF1 Inhibitor, REF-1 Inhibitor

Additional APE1 Redox Products

Product Documents for APE1 Redox Inhibitor

Product Datasheets

Certificate of Analysis

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Product Specific Notices for APE1 Redox Inhibitor

E3330 Chemical Information:
Synonym: (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid
Molecular Weight: 378.459
Empirical Formula: C21H30O6
CAS Number: 136164-66-4
HPLC purity is >= to 97%
Solubility: DMSO: >20 mg/mL
Form: powder
Color: orange

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

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