APC 366

Tocris Bioscience, part of Bio-Techne | Catalog # 2511

COA / SDS

Tryptase inhibitor

Key Product Details

Description:	Tryptase inhibitor
Chemical Name:	N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Purity:	≥95% (HPLC)
Molecular Weight:	440.5

View Full Technical Details for APC 366

Technical Data
Citations

Biological Activity for APC 366

APC 366 is a selective inhibitor of mast cell tryptase (K_i = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data for APC 366

M. Wt	440.5
Formula	C₂₂H₂₈N₆O₄
Single Letter Sequence	N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	158921-85-8
PubChem ID	177340
InChi Key	SKYWIMYOGAWOMB-IRXDYDNUSA-N
Smiles	OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for APC 366

Solubility

Soluble to 5mg/ml in 20% ethanol / water

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References for APC 366

References are publications that support the biological activity of the product.

Numerof Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs.
Barrios Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998 PMID: 9877219
He Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 2004 PMID: 14722328
He A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 1998 PMID: 9655871